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Full Time Faculty Curriculum Vitae |
Dr. Mahbuba Rahman joined the Department of Biochemistry and Microbiology at North South University as an Assistant Professor on July 1st, 2024. She earned her B.Sc. (Honors) and M.Sc. in Microbiology, as well as an M.S. in Environmental Science. She completed her PhD in Metabolic Engineering from the Department of Bioscience and Bioinformatics at Kyushu Institute of Technology, Japan.
After completing her PhD, she worked with a transgenic mouse model of Smith–Lemli–Opitz syndrome, an inborn error of cholesterol synthesis, at the Children's Hospital Research Institute (CHORI) in Oakland, California. Following this, she served as a Postdoctoral Fellow and Staff Scientist at various North American universities and in Qatar.
Dr. Rahman has published numerous research articles, both clinical and non-clinical, and as first author and co-author, in high-impact journals such as the New England Journal of Medicine, Nature Medicine, Cells, and others. She has also authored several review articles and book chapters with prominent publishers. Additionally, she is the editor of two eBooks on cancer immunotherapy and precision vaccinology for infectious diseases, and two books titled Metabolomics: A Path Towards Personalized Medicine and Metabolomics of Personalized Vaccinology. Furthermore, she serves as a special topic editor and guest editor for Frontiers in Genetics, Frontiers in Immunology, and the Journal of Microbiological Methods. She is also a reviewer for several Q1-category journals.
Dr. Rahman is also an Adjunct Assistant Professor in the Department of Biology at McMaster University. Her research interests include personalized medicine, systems biology, infectious diseases, environmental microbiology, and metabolomics.
Articles:
1. Rahman M (2024). Editorial: design considerations for future personalized vaccination approaches. Nanomedicine. doi: 10.1080/17435889.2024.2419816
2. Ogishi M........Rahman M et al., (2024). Impaired development of memory B cells and antibody responses in humans and mice deficient in PD-1 signaling. Immunity. doi: 10.1016/j.immuni.2024.10.014
3. Saleem F, Jennifer L. JIang JL, ........Rahman M, et al., (2024) Regional and Longitudinal Dynamics of Cyanobacterial Blooms/Cyanobiome and Cyanotoxin Production in the Great Lakes Area. Toxins. doi: 10.3390/toxins16110471
4. Rahman M, et al (2024) Editorial: Precision Vaccinology for Infectious Diseases. Frontiers in Immunology. doi: 10.3389/fimmu.2024.1400443.
5. Rahman M (2023) Magnetic Resonance Imaging and Iron-oxide Nanoparticles in the era of Personalized Medicine. Nanotheranostics doi: 10.7150/ntno.86467
6. Rahman M and Schellhorn HE (2023) Metabolomics of infectious diseases in the era of personalized medicine. Frontiers in Molecular Biosciences doi: 10.3389/fmolb.2023.1120376.
7. Rosain,J, Neehus AL, Manry J,…….Rahman M, et al. (2023) Human IRF1 governs macrophagic IFN-γ immunity to mycobacteria. Cell doi: 10.1016/j.cell.2022.12.038.
8. Khan TK, Rahman M, et al (2022) Human leukocyte antigen class II gene diversity tunes antibody repertoires to common pathogens. Frontiers in Immunology doi: 10.3389/fimmu.2022.856497.
9. Rahman M, et al. (2022) Editorial: Metabolomics in Infectious Diseases. Frontiers in Genetics. doi: 10.3389/fgene.2022.875835.
10. Guennoun A, Bougarn A, …..Rahman M, et al. (2021) A novel STK4 mutation impairs T cell immunity through dysregulation of cytokine-induced adhesion and chemotaxis genes. Journal of Clinical Immunology doi: 11007/s10875-021-01115-2
11. Beziat V, Rapaport F,………Rahman M, et al. (2021) Humans with inherited T cell CD28 deficiency are susceptible to skin papillomaviruses but are otherwise healthy. Cell doi: 10.1016/j.cell.2021.06.004
12. Ogishi M, Yang R, Aytekin C, Langlais D, Bourgey M, Khan T, Al-Ali F, Rahman M, et al.(2021) Inherited PD-1 deficiency underlies tuberculosis and autoimmunity in a child. Nature Medicine doi: 1038/s41591-021-01388-5
13. Hasan MR, Rahman M et al. (2021). Virome-wide serological profiling reveals association of herpesviruses with obesity. Scientific Reports doi:1038/s41598-021-82213-4
14. Khan T, Rahman M et al. (2021). Distinct antibody repertoires against endemic human coronaviruses in children and adults. Journal of Clinical Investigation Insight, doi: 1172/jci.insight.144499
15. Yu A….., Rahman M et al. (2021). Inhibition of nucleophosmin 1 suppresses colorectal cancer tumor growth of patient -derived xenografts via activation of p53 and inhibition of AKT. Cancer Biology & Therapy, doi: 10.1080/15384047.2020.1839278
16. Yang R,… Rahman M et al. (2020). Human T-bet governs innate and innate-like adaptive IFN-γ immunity against mycobacteria. Cell doi: 10.1016/j.cell.2020.10.046
17. Kerner G,……..Rahman M et al. (2020). Inherited human IFN-γ deficiency underlies mycobacterial disease. Journal of Clinical Investigations doi: 1172/jci135460
18. Drutman SB,……Rahman M, et al. (2020). Fatal Cytomegalovirus Infection in an Adult with Inherited NOS2 Deficiency. New England Journal of Medicine doi: 1056/nejmoa1910640
19. Weiswald LB, Hasan MR, Wong JC, Pasiliao CC, Rahman M, Ren J, Yin Y,Gusscott S, Vacher S, Weng AP, Kennecke HF,Bieche I, Schaeffer DF, Yapp DT, Tai IT (2017). Inactivation of the Kinase Domain of CDK10 Prevents Tumor Growth in a Preclinical Model of Colorectal Cancer, and Is Accompanied by Downregulation of Bcl-2. Mol Cancer Therapeutics doi: 10.1158/1535-7163.MCT-16-0666.
20. Rahman M and Hasan MR (2015). Cancer metabolism and drug resistance. Metabolites, 5:571-600.
21. Wong JC, Hasan MR, Rahman M, Yu AC, Chan SK, Schaeffer DF, Kennecke HF, Lim HJ, Owen D, Tai IT (2013). Nucleophosmin 1, upregulated in adenomas and cancers of the colon, inhibits p53-mediated cellular senescence. International Journal of Cancer: 133, 1567-1578.
22. Rahman M, Selvarajan K, Hasan MR, Chan APK, Jin C, Kim J, Chan S, Le ND, Kim YB and Tai IT (2012). Inhibition of COX-2 in colon cancer modulates tumor growth and MDR-1 expression to enhance tumor regression in therapy-refractory cancers in vivo. Neoplasia 14(7):624-633.
23. Rahman M, Chan APK and Tai IT (2011). A peptide of SPARC interferes with the interaction between caspase8 and Bcl2 to resensitize chemoresistant tumors and enhance their regression in vivo. PLOS ONE 6(11): e26390.
24. Matabosch X, Rahman M, Hughes B, Patel SB, Watson G, Shackleton C (2009). Steroid production and excretion by the pregnant mouse, particularly in relation to pregnancies with fetuses deficient in Delta7-sterol reductase (Dhcr7), the enzyme associated with Smith-Lemli-Opitz syndrome. J Steroid Biochem Mol Biol. 116(1-2):61-70.
25. Hasan MR, Rahman M, Jaques S, Purantini E and Daniels L (2009). Glucose-6-phosphate accumulation in mycobacteria: implications for a novel F420- dependent anti-oxidant defense system. Biol. Chem 285(25):19135-44.
26. Rahman M and Shimizu K (2008). Altered acetate metabolism and biomass production in several Escherichia coli mutants lacking rpoS dependent metabolic pathway genes. Mol Biosyst.4(2):160-9.
27. Rahman M, Hasan MR, Shimizu K (2008). Growth-phase dependent changes in the expression of global regulatory genes and associated metabolic pathways in Escherichia coli. Biotechnol Lett. 30(5):853-60.
28. Rahman M, Hasan MR, Ooba T, Shimizu K (2006). The effect of rpoS gene knockout on the metabolism of Escherichia coli during exponential growth phase and early stationary phase based on gene expressions, enzyme activities and intracellular metabolite concentrations. Biotechnol Bioeng. 94:585-95.
29. Rahman M, Rahman MM, Khan SI, Hasan MR, Islam MS (2003). Influence of temperature on the chemotaxis of Vibrio cholerae 0139 towards Anabaena Online J. Biol. Sci. 3:237-246.
Data-note:
Rahman M, Boughorbel S, Presnell S et al. A curated transcriptome dataset collection to investigate the functional programming of human hematopoietic cells in early life. F1000Research 2016, 5:414 (doi: 10.12688/f1000research.8375.1)
Protocol:
Marr AK, Blazkova J, Rahman M et al. Dataset annotation guide for the Gene Expression Browser (GXB). F1000Research 2016 (doi.org/10.7490/f1000research.1112011.1)
Book Chapters:
7. Rahman, M., et al., (2023). “Metabolomics of diabetes and cardiovascular disease”, in Metabolomics A Path Towards Personalized Medicine, Series, Developments in Applied Microbiology and Biotechnology, Editor Mahbuba Rahman. Elsevier Science, Academic Press. doi: 10.1016/B978-0-323-99924-3.00009-1
9. Azad, AK., Hakim, Al., Sohag, MMH., and Rahman. M., (2023). “Metabolomics in clinical diagnosis, prognosis, and treatment of infectious diseases”, in Metabolomics A Path Towards Personalized Medicine, Series, Developments in Applied Microbiology and Biotechnology, Editor Mahbuba Rahman. Elsevier Science, Academic Press. doi: 10.1016/B978-0-323-99924-3.00003-0
14. Rahman, M (2015) “Metabolic pathways and chemotherapy drugs”. Book entitled Frontiers in Drug Design and Discovery, Editors, Atta-ur-Rahman Bentham Science Publishers.
15. Rahman, M. (2014) “Application of Metabolic Engineering in Industrial Fermentative Process”. Book entitled Advances in Food Biotechnology. Editor Dr. Ravishankar Rai, John Wiley & Sons, Ltd.
2007 PhD (Biosciences and Bioinformatics),
Kyushu Institute of Technology, Iizuka, Japan.
Thesis title: Metabolic regulation analysis on the roles of the stress responsive global regulatory genes such as rpoS in Escherichia coli at different phases of growth in batch culture.
Advisor: Professor Kazuyuki Shimizu
2002 Master of Environmental Management, Griffith University, Brisbane, Australia.
1998 M.Sc. (Microbiology), University of Dhaka, Dhaka, Bangladesh.
Thesis title: Chemotaxis of Vibrio cholerae 0139 towards Anabaena sp. as influenced by physicochemical parameters.
1995 B.Sc. (Hons. Microbiology), University of Dhaka, Dhaka, Bangladesh.
2024-present Assistant Professor, Department of Biochemistry and Microbiology, North South University, Dhaka, Bangladesh.
2023-present Adjunct Assistant Professor, Department of Biology, McMaster University, Hamilton, ON, Canada
2021-2022 Facilitator and Lecturer, REACH program, Novartis, Bangladesh.
2021 Postdoctoral Fellow, Translational Cancer Immunity Center, Biomedical Research Institute (QBRI), Doha, Qatar
2015-2020 Staff Scientist, Department of Systems Biology and Immunology, Sidra Medicine, Doha, Qatar
2010-2013 Postdoctoral Fellow, Department of Medicine, University of British Columbia at Genome Sciences Centre, BC Cancer Research Centre, Vancouver, BC, Canada
2009 Postdoctoral Fellow, Department of Microbiology, University of British Columbia, Vancouver, BC, Canada
2008 Postdoctoral Research Associate, Irma Lerma Rangel College of Pharmacy, Texas A&M Health Science Center, Kingsville, Texas, USA
2007 Researcher, Children’s Hospital Oakland Research Institute (CHORI), Oakland, California, USA
2006-2007 Research Assistant, Department of Bioscience and Bioinformatics, Kyushu Institute of Technology, Iizuka, Japan
2001 Laboratory Technician, Microbiological Quality Assurance Laboratory, Cook Australia (a biomedical equipment manufacturing company).
1999-2000 Research Officer, STD Lab, Laboratory Sciences Division (LSD), International Centre for Diarrhoeal Disease Research, Bangladesh (ICDDR,B), Dhaka, Bangladesh
1998-1999 Quality Control Officer, Beximco Infusions Ltd., Tongi, Bangladesh
1995-1997 Research Student, Environmental Microbiology Laboratory, LSD, ICDDR,B, Dhaka, Bangladesh.
Bio 202, MIC 314, MIC 309, MIC 207, BIO 202L, BIO 103L
The International Society of Bangladesh Affiliated Microbiologists (ISBM)
Personalized Medicine
Environmental Microbiology
Metabolomics
Infectious Diseases