Curriculum

Program: MPharm in PTB

Duration: 1 year~                   Total Credit Hours: 36                   No. of Semesters: 4~

MPharm in PTB (Thesis):

MPharm in PTB (Non-Thesis):

List of Courses

Semester-wise Distribution of Courses

Semester-I:      

Semester-II:                             

Semester-III:                           

Semester-IV:                           

Course Description

Core courses

PHR5001

Advanced Pharmacology-I

Use of laboratory animal for experiments. Alternatives to animal studies. Overview of preclinical testing. Preclinical evaluation of different categories of drugs including sedatives, anxiolytics, antidepressants, antipsychotics, antiparkinson drugs, analgesics, anti-inflammatory agents, CNS stimulants, cardiovascular drugs, antiulcer agents, laxatives, bronchodilators, histamine antagonists, muscle relaxants, anticholinergics, hypoglycemics, antifertility agents, anti-thyroid agents, dermatological agents, antitumor agents, antimalarials, etc. In vitro testing of drugs. Limitations of in vitro testing of drugs.

PHR5002

Advanced Pharmaceutical Analysis

Spectroscopic Methods such as UV, IR, NMR, and Mass Spectroscopy with examples. Theory, instrumentation, and applications of different separation techniques such as GLC, HPLC, HPTLC, chiral chromatography, lon pair chromatography and capillary electrophoresis. Theory, instrumentation, and applications of thermal analysis. Different immunochemical techniques including immunoelectrophoresis, immunoprecipitation, ELISA, and radioimmuno assays. Introduction to Quality Assurance Techniques.

PHR5003

Advanced Statistics in Pharmaceutical Sciences

Statistics and its application in pharmaceutical and biomedical sciences. Populations and samples. Classification, tabulation and presentation of data. Frequency distributions. Hypothesis testing: concepts, types, p-value.  Test of significance: parametric tests (t-test, One way ANOVA, multiple comparison tests); Two-way ANOVA; nonparametric tests. Regression and correlation, Chi-square & odds ratio. Biostatistics for clinical trials. Study design & types of studies. Sampling & sample size determination.  Statistical tests for bioequivalence.  Analysis of data using statistical programs. 

Specialized courses

PHR5021

Advanced Pharmaceutical Technology

Advanced Tablet Technology: Wet granulation, dry granulation & direct compression. Granulation of powders for tableting. Physics of tablet compression, different stages of tablet compression, problems associated with large scale manufacturing of tablet. Advanced drug delivery systems: Transdermal drug delivery system, mucosal drug delivery system, nasal drug delivery system, ocular drug delivery system, intrauterine drug delivery system, liposomes and nanoparticles drug delivery system, biodegradable drug delivery system, hydrogel based drug delivery system, drug delivery to the lungs, metered dose inhalers and dry powder inhalers. Pilot Plant scale-up techniques. Formulation and research of biotech products including hematopoietic growth factors, interlukins and interferons, insulin, growth hormones, vaccines, monoclonal antibody-based pharmaceuticals, recombinant tissue type plasminogen, recombinant human deoxyribonuclease, and follicle stimulating hormone(FSH).   

PHR5022

Advanced Pharmaceutics

Solids: Characterization and handling of solids, pharmaceutical granulation, compression and compaction properties of binary mixtures, lubricant sensitivity, characterization of granules and compacts.  Dissolution: Theory of dissolution and drug release, dissolution test apparatus, dissolution of different dosage forms. Surfactant System: Phase behavior of surfactant in binary and ternary systems, factors affecting phase behavior, micellization. Pharmaceutical aspects of solubilization. Biological implications of surfactants. Polymer science: Types and applications of polymers, polymerization reactions, methods of polymerization and characterization of polymers, thermodynamics of polymer solutions. Solid dispersions: Types, methods of preparation, selection of carrier, characterization and applications. Stability studies.

PHR5023

Advanced Biopharmaceutics and Pharmacokinetics

Clinical pharmacokinetics and its importance. Distribution of drugs: Factors affecting distribution of drugs, volume of distribution, clinical concepts and kinetics of physiological parameters of distribution. Elimination of drug: Concept of clearance, hepatic metabolism, renal excretion, non-renal excretion. Bioavailability: Objective of bioavailability studies, determination bioavailability, relative bioavailability, in vitro drug dissolution testing models, in vitro – in vivo correlation, in vitro and in situ absorption studies. Nonlinear pharmacokinetics. MRT and Statistical moment analysis. Pharmacokinetics and pharmacologic response. Therapeutic Drug Monitoring (TDM):  Introduction to TDM, techniques used in TDM, variation in clinical laboratory tests due to drugs, TDM of specific drugs such as Digoxin, Lithium, Phenobarbitone, Gentamicin, Theophylline, Carbamazepine, Lidocaine, Phenytoin, and Valproic acid.

PHR 5209

Pharmaceutical Industrial Management

Pilot plant scale-up pilot plant design: tablets, capsules, liquid orals. Parenterals, and semisolid preparations. Personnel, pharmaceutical process validation for various products. Quality Assurance: GMP considerations, quality assurance and process control. Total quality management and productivity. ISO 9000 Salient features. Optimization Techniques: Optimization parameters, classical optimization, statistical design and applied optimization methods. Production Planning: Plant site selection, layout and organization of pharmaceutical industrial. Machinery Engineering: Introduction to mechanical, electrical and electronic parts of pharmaceutical machinery, equipment. Safety: Industrial hazards due to fire, accident, mechanical and electrical equipment, chemical and pharmaceuticals, monitoring and preventive system. Effluent testing and treatment. Automation: Flexible manufacturing system, computer control systems, typical models for solid and liquid manufacturing.

Elective courses

PHR5101

Pharmaceutical Marketing and Brand Management

Introduction to Pharmaceutical Marketing and Brand Management. Pricing of drugs. Market Promotion: Approaches; promotional plan; advertising of drugs; measuring effectiveness.  Market demand and forecasting: Understanding market demand; anatomy of a market; patterns; forecasting and planning. Pharmaceutical Brand Management: Definitions, brand management responsibilities, brand management across the product life cycle, brand analysis and research, market analysis and segmentation for pharmaceutical branding.

PHR5106

Pharmaceutical Biotechnology

Industrial Microorganisms: Source, characteristics, growth and genetics. Development of Industrial Fermentation Processes: Screening, detection and assay of fermentation products, stick cultures, fermentation media, inoculum preparation, scale up of fermentations, increasing product yields, fermentation economics. Industrial fermentor. Antibiotic fermentation: Properties, Biosynthesis and Fermentation of Antibacterial antibiotics –Penicillin, tetracyclines, aminoglycosides, chloramphenicol and macrolides. Antibiotic Production by immobilized living cells. Enzyme Fermentation: Amylases, proteolytic enzymes. Other fermentation: Acetonebutanol, citric acid, glycerol, industrial alcohol, yeast and vitamins. Downstream Processing: Harvesting, cell disintegration, clarification of crude extract, product enrichment, precipitation, ultrafiltration, extraction, chromatography. Biotechnology product formulation, stability studies, quality control, packaging.  

PHR5107

Cellular and Molecular Biology

The course is designed for in-depth approach to biological topics.  It introduces the physical and chemical organization of living organisms; cell structure, function, and metabolism; classical and molecular genetics; gene regulation; genetic engineering and evolution. Particular emphasize will be given to cancer biology, cell Control by cell cycle and signal transduction pathways and different therapeutic approaches from molecular point of view (such as protein kinase inhibitors, immunotherapy, radiation therapy, therapy in cardiovascular diseases).

PHR5108

Drug Regulatory Affairs 

Working techniques and tools needed to examine and register pharmaceuticals for human use at home and abroad. Accepted standards of harmonization and technical requirements for the registration of pharmaceuticals for human use; approval process, format and registration of pharmaceuticals in Bangladesh. Drug Regulatory Affairs and Intellectual Property Rights, Documentation and Maintenance of records, Environment protection Act. Professional characteristic and ethical norms, relationship of trust, ethical considerations during pharmacy practice, deficiencies of self-regulation, adherence of self-regulation. The pharmacist’s code of ethics. Government health and drug policies.

PHR5201

Drug Design

A general study of co-relation of physico-chemical properties, and stereochemistry and drug action. Isosterism and bio-isosterism as guides to structural variations, metabolite, antagonism and theory of drug action.  An overall treatment of the approaches to drug design, including the method of variation, study of the use of biochemical and physiological information in evolving new drugs and basis of design.  The basis of drugs design and recent advances: Antihypertensive agents, Antineoplastic agents, Anti-AIDS agents, Antipsychotic agents, GABA-nergic agonists, Chemistry of Betalactam antibiotics. Drug design based on antagonism and enzyme inhibition. Molecular modelling in Drug Design. Approaches to the rational Design of Enzyme Inhibitors: Introduction, enzyme inhibitors in medicine, enzyme inhibitors in basic research, Rational Design of Non covalently & covalently binding Enzyme inhibitors, Rapid reversible inhibitors, slow & tight binding inhibitors, transistion state analogs, multisubstrate inhibitors.

PHR5208

Quality Control and Quality Assurance

Concept of chemical, biochemical and clinical equivalence methods and their appraisal to study identity, purity and content uniformity of drugs. Quality Control: Sampling techniques; analytical, biological and clinical testing. Study of stability. Bioavailability of products. Quality Control, and evaluation of package performance. Applications of Statistical methods for assessment of reliability and reproducibility of results: random selection of samples for testing. In-process quality control for manufacturing reliability. Development of drug information profiles. Various pharmacopoeias of different countries. Good Manufacturing Practices.

Course Outline

Highlights

• Upto 100% scholarships
• World-class research facilities
• Evening & weekend classes
• Classes conducted by PhD faculty members only