Curriculum

Program: MPharm in PCP

Duration: 1 year~                 Total Credit Hours: 36                   No. of Semesters: 4~

MPharm in PCP (Thesis):

 MPharm in PCP (Non-Thesis):

 List of Courses

 Semester-wise Distribution of Courses

Semester-I:      

Semester-II:                             

Semester-III:                           

Semester-IV:                           

Course Description

Core courses

PHR5001

Advanced Pharmacology-I

Use of laboratory animal for experiments. Alternatives to animal studies. Overview of preclinical testing. Preclinical evaluation of different categories of drugs including sedatives, anxiolytics, antidepressants, antipsychotics, antiparkinson drugs, analgesics, anti-inflammatory agents, CNS stimulants, cardiovascular drugs, antiulcer agents, laxatives, bronchodilators, histamine antagonists, muscle relaxants, anticholinergics, hypoglycemics, antifertility agents, anti-thyroid agents, dermatological agents, antitumor agents, antimalarials, etc. In vitro testing of drugs. Limitations of in vitro testing of drugs.

PHR5002

Advanced Pharmaceutical Analysis

Spectroscopic Methods such as UV, IR, NMR, and Mass Spectroscopy with examples. Theory, instrumentation, and applications of different separation techniques such as GLC, HPLC, HPTLC, chiral chromatography, lon pair chromatography and capillary electrophoresis. Theory, instrumentation, and applications of thermal analysis. Different immunochemical techniques including immunoelectrophoresis, immunoprecipitation, ELISA, and radioimmuno assays. Introduction to Quality Assurance Techniques.

PHR5003

Advanced Statistics in Pharmaceutical Sciences

Statistics and its application in pharmaceutical and biomedical sciences. Populations and samples. Classification, tabulation and presentation of data. Frequency distributions. Hypothesis testing: concepts, types, p-value.  Test of significance: parametric tests (t-test, One way ANOVA, multiple comparison tests); Two-way ANOVA; nonparametric tests. Regression and correlation, Chi-square & odds ratio. Biostatistics for clinical trials. Study design & types of studies. Sampling & sample size determination.  Statistical tests for bioequivalence.  Analysis of data using statistical programs. 

Specialized courses

PHR5011

Advanced Pharmacology-II

Clinical evaluation of new drugs. Organization, Ethics and protocol for clinical trials. Therapeutic drug monitoring Principles. Clinical pharmacology of cardiovascular drugs. Analgesics and antipyretics.  Immunopharmacology: current concepts in theory and research of drugs for AIDS. Vaccines and sera, Drug allergy, Tissue transplantation, Immunostimulants, Immunomodulaters Immunosuppressant. Knowledge of various in vitro and in vivo tests carried out in immunological investigation. Pharmacotherapy of Gastrointestinal diseases. Pharmacotherapy of Renal diseases. Pharmacotherapy of Respiratory diseases. Pharmacotherapy of Hepatic disorders. Pharmacotherapy of Infectious diseases. Pharmacotherapy of Neoplastic disorders.

PHR5012

Toxicology & Safety Pharmacology

Fundamental Principles: Introduction, Toxicological Evidence, Common household poisons, description of sub disciplines of toxicology, qualitative and quantitative aspects of toxic effects. Biotransformation: detoxication and bioactivation. Absorption, distribution and elimination of xenobiotics. Toxicokinetics ; quantitative aspect. Dose time – effect relationships. Molecular aspects of toxicology. Organ toxicology. Necrosis and apoptosis. Dermatotoxicology. Raspiratory toxicology. Gastrointstinal toxicology. Hepatotoxicology. Nephotoxicology. Cardiovascular toxicology. Toxicology of blood. Immunoxicology. General reproductive toxicology. Functional neurotoxicology.  Medical and clinical toxicology. Ecotoxicology. Occupational toxicology. Carcinogencity. Teratogenicity.

PHR5013

Clinical Pharmacy

Introduction to Clinical Pharmacy. Fundamentals of diseases: Symptoms & disease identification, communicable disease prevention. Therapeutic use of medicine: Drug Selection & Administration, Reasons for noncompliance, Strategies for Improving Compliance, Use of drugs in Geriatric, Pediatric patients & in Pregnancy. Monitoring the patient in health & illness:  Fluid & electrolyte imbalance, Cardio-pulmonary dysfunction, Metabolic disorders, Patient follow-up, Discharge interview for hospitalized patients Precautions & Directions during use of medication. Pharmacological & biochemical examinations, their significance. Supervision of therapeutic success, side effects & adverse effects.  Drug information. Therapeutic management of following diseases: Myocardial ischemia, Miocardial infraction, Conjestive cardiac failure, Cardiac arrhythmias, Hypertension, Hyperlipidema,  Acute renal failure, Chronic renal failure,  Respiratory disorders: Bronchial asthma, Chronic obstructive lung disease. Clinical testing of drugs: Introduction, various phases, ICH guidelines, regulatory affairs.

PHR5015

Drug Use Management

Problems of Irrational Use of Drugs: Background, definition of rational use of drugs; Factors affecting irrational use of drugs; Impact of irrational use of drugs; Examples of irrational use of drugs; Drug use patterns in developed and developing countries. Sampling to study drug use. Drug use indicator study. Changing Drug Use Practices: Factor influencing drug use; Intervention strategies; Farmework for changing drug use practices; Decisions Making for Rational Use Intervention. Role of Dispensers in Promoting Drug Use Management: Introduction, Definition of dispenser, Dispensing process, Proper and improper dispensing, Impact of improper dispensing. Effective Public Education: Introduction, Patients, role, Concept of disease etiology; Concept of cure, Concepts  about the therapeutic values of drugs;  Effect of promotion and marketing on the use of drugs. Standard Treatment: Introduction, Importance of standard treatment guidelines, Standard treatment in the therapeutic process, Advantages of standard treatment. Standard treatment guidelines for health centers.

Elective courses

PHR5101

Pharmaceutical Marketing and Brand Management

Introduction to Pharmaceutical Marketing and Brand Management. Pricing of drugs. Market Promotion: Approaches; promotional plan; advertising of drugs; measuring effectiveness.  Market demand and forecasting: Understanding market demand; anatomy of a market; patterns; forecasting and planning. Pharmaceutical Brand Management: Definitions, brand management responsibilities, brand management across the product life cycle, brand analysis and research, market analysis and segmentation for pharmaceutical branding.

PHR5106

Pharmaceutical Biotechnology

Industrial Microorganisms: Source, characteristics, growth and genetics. Development of Industrial Fermentation Processes: Screening, detection and assay of fermentation products, stick cultures, fermentation media, inoculum preparation, scale up of fermentations, increasing product yields, fermentation economics. Industrial fermentor. Antibiotic fermentation: Properties, Biosynthesis and Fermentation of Antibacterial antibiotics –Penicillin, tetracyclines, aminoglycosides, chloramphenicol and macrolides. Antibiotic Production by immobilized living cells. Enzyme Fermentation: Amylases, proteolytic enzymes. Other fermentation: Acetonebutanol, citric acid, glycerol, industrial alcohol, yeast and vitamins. Downstream Processing: Harvesting, cell disintegration, clarification of crude extract, product enrichment, precipitation, ultrafiltration, extraction, chromatography. Biotechnology product formulation, stability studies, quality control, packaging.  

PHR5107

Cellular and Molecular Biology

The course is designed for in-depth approach to biological topics.  It introduces the physical and chemical organization of living organisms; cell structure, function, and metabolism; classical and molecular genetics; gene regulation; genetic engineering and evolution. Particular emphasize will be given to cancer biology, cell Control by cell cycle and signal transduction pathways and different therapeutic approaches from molecular point of view (such as protein kinase inhibitors, immunotherapy, radiation therapy, therapy in cardiovascular diseases).

PHR5108

Drug Regulatory Affairs 

Working techniques and tools needed to examine and register pharmaceuticals for human use at home and abroad. Accepted standards of harmonization and technical requirements for the registration of pharmaceuticals for human use; approval process, format and registration of pharmaceuticals in Bangladesh. Drug Regulatory Affairs and Intellectual Property Rights, Documentation and Maintenance of records, Environment protection Act. Professional characteristic and ethical norms, relationship of trust, ethical considerations during pharmacy practice, deficiencies of self-regulation, adherence of self-regulation. The pharmacist’s code of ethics. Government health and drug policies.

PHR5201

Drug Design

A general study of co-relation of physico-chemical properties, and stereochemistry and drug action. Isosterism and bio-isosterism as guides to structural variations, metabolite, antagonism and theory of drug action.  An overall treatment of the approaches to drug design, including the method of variation, study of the use of biochemical and physiological information in evolving new drugs and basis of design.  The basis of drugs design and recent advances: Antihypertensive agents, Antineoplastic agents, Anti-AIDS agents, Antipsychotic agents, GABA-nergic agonists, Chemistry of Betalactam antibiotics. Drug design based on antagonism and enzyme inhibition. Molecular modelling in Drug Design. Approaches to the rational Design of Enzyme Inhibitors: Introduction, enzyme inhibitors in medicine, enzyme inhibitors in basic research, Rational Design of Non covalently & covalently binding Enzyme inhibitors, Rapid reversible inhibitors, slow & tight binding inhibitors, transistion state analogs, multisubstrate inhibitors.

PHR5208

Quality Control and Quality Assurance

Concept of chemical, biochemical and clinical equivalence methods and their appraisal to study identity, purity and content uniformity of drugs. Quality Control: Sampling techniques; analytical, biological and clinical testing. Study of stability. Bioavailability of products. Quality Control, and evaluation of package performance. Applications of Statistical methods for assessment of reliability and reproducibility of results: random selection of samples for testing. In-process quality control for manufacturing reliability. Development of drug information profiles. Various pharmacopoeias of different countries. Good Manufacturing Practices.

Course Outline

HIghlights

• Upto 100% scholarships
• World-class research facilities
• Evening & weekend classes
• Classes conducted by PhD faculty members only